Enzyme in pancreatic juice

A healthy pancreas produces about 4 litres of pancreatic juice into the duodenum each day. This juice contains pancreatic enzymes. Pancreatic enzymes are made in the pancreas and aid digestion in the gut. Thus pancreatic enzymes are digestive enzymes but, as we will see, not all digestive enzymes are produced in the pancreas. The juice contains a number of important digestive enzymes , including trypsin , chymotrypsin , carboxypeptidase, lipase , and amylase . Pancreatic juice is alkaline in nature because of a high concentration of bicarbonate ions; this helps to neutralize the acidic gastric juice from the stomach. Secretion of pancreatic juice is stimulated by The enzymes help to make proteins, fats and carbohydrates smaller. This helps the guts (intestines) to absorb these nutrients. The acinar cells also make a liquid which creates the right conditions for pancreatic enzymes to work. This is also known as pancreatic juice. The enzymes …

All the enzymes of pancreatic juice are secreted into duodenum in the inactive form, if not enzymes themselves will digest the entire pancreas. Besides this, trypsin has got a specific inhibitor in the pancreas itself. Chymotrypsinogen: This is also an endopeptidase. Chymotrypsinogen is activated to chymotrypsin by trypsin. Pancreatic juice is a liquid secreted by the pancreas, which contains a variety of enzymes, including trypsinogen, chymotrypsinogen, elastase, carboxypeptidase, pancreatic lipase, and amylase. HCO 3 in pancreatic juice neutralizes gastric acid, and provides an optimal pH environment for digestive enzymes to function in the duodenum (74). In addition, HCO 3 − acts as a moderate chaotropic ion that facilitates the solubilization of macromolecules, such as digestive enzymes and mucins (42).

Assertion: Trypsinogen is activated by enterokinase into active trypsin which in turn activates other enzymes in the pancreatic juice Reason: The pancreatic juice contains inactive enzymes which are activated by intestinal juice.